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The Apothecary Diaries Episode 46 Preview: Maomao’s Promise and the Forbidden Army March

The Apothecary Diaries Episode 46 Preview: Maomao’s Promise and the Forbidden Army March

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The second cour of Season 2 of the hit spring anime The Apothecary Diaries (Kusuriya no Hitorigoto) is nearing its climax. Episode 46, titled “Forbidden Army” (禁軍), airs on Friday, June 13, 2025, and preview images along with a synopsis have just been released. Following the episode, the full-length anime music video for the opening theme “Kusushiki” by Mrs. GREEN APPLE will premiere on TOHO animation’s YouTube channel at 11:30 PM JST.

アニメ『薬屋のひとりごと』第46話「禁軍」先行カット


Episode 46 Summary: "Forbidden Army"

The fortress is engulfed in flames after Rouran sets fire to the gunpowder store. Reunited in the chaos, Maomao confronts Rouran, learning about her painful past and inner resolve. Despite Maomao’s attempts to stop her, Rouran insists on fulfilling her mission and heads toward Shinbi. Before parting, Maomao promises her “something”—a detail yet to be revealed but clearly of deep emotional weight.

Meanwhile, the Imperial Guard (Forbidden Army)—a direct force under the Emperor’s command—approaches the fortress. Jinshi, clad in regal purple and navy armor, leads the charge, signaling the start of the battle against the rebellious Ko Clan.


More Than Just an Episode: MV Premiere Announcement

Following the broadcast of episode 46, fans can look forward to the anime MV premiere of “Kusushiki,” the current opening theme performed by Mrs. GREEN APPLE. The music video will feature full-length visuals, including key scenes from the latest episodes, blending poetic lyrics and Omori Motoki’s music with emotionally charged animation.


Series Overview

Based on the best-selling novel by Natsu Hyuuga, with over 40 million copies in circulation, The Apothecary Diaries is a historical mystery drama set in a fictional East Asian court. The story follows Maomao, a sharp-witted young woman working as a palace poison tester, as she solves complex mysteries and political intrigues within the inner chambers of the royal court.

Since the premiere of Season 2 in January 2025, the anime has consistently ranked among the top-viewed shows on streaming platforms. With large-scale events like the official exhibition (launched March 26) and an upcoming collaboration at Universal Studios Japan this summer, the series is clearly at the height of its popularity.


Don’t Miss Episode 46!

📺 The Apothecary Diaries Season 2, Episode 46 “Forbidden Army” airs on June 13 at 11:00 PM JST via Nippon TV’s Friday Anime Night (Fura-Ani) block.
🎶 The “Kusushiki” MV premieres at 11:30 PM JST on the TOHO animation YouTube channel.

Stay tuned for what promises to be a dramatic and emotional turning point in Maomao’s story.